Ocular adverse effects are mostly caused by compounds administered via the ocular route, but they can also be generated by systemic administration.

Electroretinography allows the assessment of retinal function in an easy and efficient manner. The electroretinogram (ERG) is an objective ocular diagnostic test, which measures electrical responses of retinal cells produced by the standardized flashes of light.

In pre-clinical studies, electroretinography can be used as an efficacy measure, helping in determining the dosage to be given to the patient. ERG is recommended to be used when the drug candidate suffers of retinal lesions or binds to melanin.

Similarly, in clinical trials, electroretinograms can be recorded as secondary endpoints in support of primary endpoints such as long-term clinical management. When retinal abnormalities are demonstrated in pre-clinical studies, ERGs are recommended as this test will suggest that the effect was species-related.

RETevet™ and RETeval® are handheld, completely portable and FDA-cleared full field flash ERG devices intended for use in animals and humans, respectively. LKC’s devices are capable of helping you obtain quick, high volume results, crucial in large studies featuring multiple measurements.

ERGs are easy to run as well as accurate, repeatable, and results are generated in a easy to read PDF format and are a great addition to your practice